afflict, affliction, aggravate, aggravation, ail, ambulatory plague
, anguish, annoy, annoyance, apply pressure, badger, bait, bane, be at, be the matter, bedevil, beleaguer, beset, besiege, bevy, bitch, black death, black plague
, blandish, blight, bother, bristle, brown off, bubonic plague
, bug, bugbear, bullyrag, burden, burn up, buttonhole, cajole, calamity, cellulocutaneous plague
, chafe, charm, chevy, chivy, cloud, coax, complicate matters, concern, covey, crawl with, creep with, crushing burden, curse, death, defervescing plague
, destruction, devil, discommode, discompose, disease, distemper, distress, disturb, dog, drag, dun, epidemic, epiphytotic, epizootic, evil, exasperate, exercise, exert pressure, fash, flight, flock, fret, gaggle, gall, get, glandular plague
, gnaw, grievance, gripe, harass, harm, harry, hassle, haunt, headache, heckle, hector, hemorrhagic plague
, hive, hound, importune, inconvenience, infest, infestation, infliction, invade, invasion, irk, irritate, irritation, larval plague
, lousiness, miff, molest, murmuration, murrain, nag, nag at, needle, nemesis, nettle, nudzh, nuisance, open wound, overrun, overrunning, overspread, overspreading, overswarm, overswarming, pandemia, pandemic, peeve, perplex, persecute, perturb, pest, pester, pesthole, pestilence, pick on, pique, plague
spot, pluck the beard, ply, pneumonic plague
, pother, premonitory plague
, press, pressure, provoke, push, put out, put to it, puzzle, ravage, ride, rile, roil, ruffle, running sore, scourge, septicemic plague
, siderating plague
, skein, spring, swarm, swarm with, swarming, tease, teeming, thorn, torment, torture, trouble, try the patience, tuberculosis, tweak the nose, urge, vex, vexation, visitation, watch, wheedle, white plague
, woe, work on, worry
disease, illness, sickness, ailing, all the ills that flesh is heir to, morbidity, morbosity, infirmity, ailment, indisposition, complaint, disorder, malady, distemper, distemperature, visitation, attack, seizure, stroke, fit, delicacy, loss of health, invalidation, cachexy, cachexia, atrophy, marasmus, indigestion, dyspepsia, decay, decline, consumption, palsy, paralysis, prostration, taint, pollution, infection, sepsis, septicity, infestation, epidemic, pandemic, endemic, epizootic, murrain, plague
, pestilence, pox, sore, ulcer, abscess, fester, boil, pimple, wen, carbuncle, gathering, imposthume, peccant humor, issue, rot, canker, cold sore, fever sore, cancer, carcinoma, leukemia, neoplastic disease, malignancy, tumor, caries, mortification, corruption, gangrene, sphacelus, sphacelation, leprosy, eruption, rash, breaking out, fever, temperature, calenture, inflammation, ague, angina pectoris, appendicitis, Asiatic cholera, spasmodic cholera, biliary calculus, kidney stone, black death, bubonic plague
, pneumonic plague
, blennorrhagia, blennorrhoea, blood poisoning, bloodstroke, bloody flux, brash, breakbone fever, dengue fever, malarial fever, Q-fever, heart attack, cardiac arrest, cardiomyopathy, hardening of the arteries, arteriosclerosis, atherosclerosis, bronchocele, canker rash, cardialgia, carditis, endocarditis, cholera, asphyxia, chlorosis, chorea, cynanche, dartre, enanthem, enanthema, erysipelas, exanthem, exanthema, gallstone, goiter, gonorrhea, green sickness, grip, grippe, influenza, flu, hay fever, heartburn, heaves, rupture, hernia, hemorrhoids, piles, herpes, itch, king's evil, lockjaw, measles, mumps, polio, necrosis, pertussis, phthisis, pneumonia, psora, pyaemia, pyrosis, quinsy, rachitis, ringworm, rubeola, St. Vitus's dance, scabies, scarlatina, scarlet fever, scrofula, seasickness, struma, syntexis, tetanus, tetter, tonsillitis, tonsilitis, tracheocele, trachoma, trismus, varicella, varicosis, variola, water qualm, whooping cough, yellow fever, yellow jack, fatal disease, dangerous illness, galloping consumption, churchyard cough, general breaking up, break up of the system, idiocy insanity, martyr to disease, cripple, the halt the lame and the blind, valetudinary, valetudinarian, invalid, patient, case, sickroom, sick- chamber, pathology, etiology, nosology, anthrax, bighead, blackleg, blackquarter, cattle plague
, glanders, mange, scrapie, milk sickness, heartworm, feline leukemia, roundworms, quarter-evil, quarter-ill, rinderpest, virus, bacterium, bacteria, DNA virus, RNA virus, rhinovirus, rhabdovirus, picornavirus, herpesvirus, cytomegalovirus, CMV, human immunodefficiency virus, HIV, diseased, ailing, ill, ill of, taken ill, seized with, indisposed, unwell, sick, squeamish, poorly, seedy, affected with illness, afflicted with illness, laid up, confined, bedridden, invalided, in hospital, on the sick list, out of health, out of sorts, under the weather, valetudinary, unsound, unhealthy, sickly, morbid, morbose, healthless, infirm, chlorotic, unbraced, drooping, flagging, lame, crippled, halting, morbid, tainted, vitiated, peccant, contaminated, poisoned, tabid, mangy, leprous, cankered, rotten, rotten to the core, rotten at the core, withered, palsied, paralytic, dyspeptic, luetic, pneumonic, pulmonic, phthisic, rachitic, syntectic, syntectical, tabetic, varicose, touched in the wind, broken-winded, spavined, gasping, hors de combat, weakly, weakened, decrepit, decayed, incurable, in declining health, cranky, in a bad way, in danger, prostrate, moribund, morbific epidemic, endemic, zymotic.
mental suffering, pain, dolor, suffering, sufferance, ache, smart, passion, displeasure, dissatisfaction, discomfort, discomposure, disquiet, malaise, inquietude, uneasiness, vexation of spirit, taking, discontent, dejection, weariness, anhedonia, annoyance, irritation, worry, infliction, visitation, plague
, bore, bother, botheration, stew, vexation, mortification, chagrin, esclandre, mauvais quart d'heur, care, anxiety, solicitude, trouble, trial, ordeal, fiery ordeal, shock, blow, cark, dole, fret, burden, load, concern, grief, sorrow, distress, affliction, woe, bitterness, heartache, carking cares, heavy heart, aching heart, bleeding heart, broken heart, heavy affliction, gnawing grief, unhappiness, infelicity, misery, tribulation, wretchedness, desolation, despair, extremity, prostration, depth of misery, nightmare, ephialtes, incubus, pang, anguish, agony, torture, torment, purgatory, hell upon earth, iron age, reign of terror, slough of despond, peck of troubles, ills that flesh is heir to, miseries of human life, unkindest cut of all, sufferer, victim, prey, martyr, object of compassion, wretch, shorn lamb, in pain, in a state of pain, full of pain, suffering, pained, afflicted, worried, displeased, aching, griped, sore, on the rack, in limbo, between hawk and buzzard, uncomfortable, uneasy, ill at ease, in a taking, in a way, disturbed, discontented, out of humor, weary, heavy laden, stricken, crushed, a prey to, victimized, ill-used, unfortunate, to be pitied, doomed, devoted, accursed, undone, lost, stranded, fey, unhappy, infelicitous, poor, wretched, miserable, woe-begone, cheerless, careworn, concerned, sorry, sorrowing, sorrowful, cut up, chagrined, horrified, horror-stricken, in grief, plunged in grief, a prey to grief, in tears, steeped to the lips in misery, heart-stricken, heart-broken, heart-scalded, broken-hearted, in despair, the iron entered into our soul, haeret lateri lethalis arundo, one's heart bleeding, down, thou climbing sorrow, mirth cannot move a soul in agony, nessun maggior dolere che ricordarsi del tempo fel, sorrow's crown of sorrow is remembering happier th, the Niobe of Nations.
painfulness, trouble, care, trial, affliction, infliction, blow, stroke, burden, load, curse, bitter pill, bitter draught, waters of bitterness, annoyance, grievance, nuisance, vexation, mortification, sickener, bore, bother, pother, hot water, sea of troubles, hornet's nest, plague
, pest, cancer, ulcer, sting, thorn, canker, scorpion, dagger, scourge, carking care, canker worm of care, mishap, misfortune, desagrement, esclandre, rub, source of irritation, source of annoyance, wound, open sore, sore subject, skeleton in the closet, thorn in the flesh, thorn in one's side, where the shoe pinches, gall and wormwood, sorry sight, heavy news, provocation, affront, head and front of one's offending, infestation, molestation, malignity, causing pain, hurting, hurtful, painful, dolorific, dolorous, unpleasant, unpleasing, displeasing, disagreeable, unpalatable, bitter, distasteful, uninviting, unwelcome, undesirable, undesired, obnoxious, unacceptable, unpopular, thankless, unsatisfactory, untoward, unlucky, uncomfortable, distressing, afflicting, afflictive, joyless, cheerless, comfortless, dismal, disheartening, depressing, depressive, dreary, melancholy, grievous, piteous, woeful, rueful, mournful, deplorable, pitiable, lamentable, sad, affecting, touching, pathetic, irritating, provoking, stinging, annoying, aggravating, mortifying, galling, unaccommodating, invidious, vexatious, troublesome, tiresome, irksome, wearisome, plaguing, plaguy, awkward, importunate, teasing, pestering, bothering, harassing, worrying, tormenting, carking, intolerable, insufferable, insupportable, unbearable, unendurable, past bearing, not to be borne, not to be endured, more than flesh and blood can bear, enough to drive one mad, enough to provoke a saint, enough to make a parson swear, enough to gag a maggot, shocking, terrific, grim, appalling, crushing, dreadful, fearful, frightful, thrilling, tremendous, dire, heart-breaking, heart-rending, heart-wounding, heart-corroding, heart-sickening, harrowing, rending, odious, hateful, execrable, repulsive, repellent, abhorrent, horrid, horrible, horrific, horrifying, offensive, nauseous, nauseating, disgusting, sickening, revolting, nasty, loathsome, loathful, fulsome, vile, hideous, sharp, acute, sore, severe, grave, hard, harsh, cruel, biting, caustic, cutting, corroding, consuming, racking, excruciating, searching, grinding, grating, agonizing, envenomed, catheretic, pyrotic, ruinous, disastrous, calamitous, tragical, desolating, withering, burdensome, onerous, oppressive, cumbrous, cumbersome, painfully, with pain, deuced, Int, hinc illae lachrymae!, surgit amari aliquid, the place being too hot to hold one, the iron entering into the soul, he jests at scars that never felt a wound, I must be cruel only to be kind, what deep wounds ever closed without a scar?.
cause pain, occasion pain, give pain, bring pain, induce pain, produce pain, create pain, inflict pain, pain, hurt, wound, pinch, prick, gripe, pierce, lancinate, cut, hurt the feelings, wound the feelings, grate upon the feelings, grate upon the nerves, jar upon the feelings, wring the heart, pierce the heart, lacerate the heart, break the heart, rend the heart, make the heart bleed, tear the heart strings, rend the heart strings, draw tears from the eyes, sadden, make unhappy, plunge into sorrow, grieve, fash, afflict, distress, cut up, cut to the heart, displease, annoy, incommode, discompose, trouble, disquiet, faze, feaze, feeze, disturb, cross, perplex, molest, tease, tire, irk, vex, mortify, wherret, worry, plague
, bother, pester, bore, pother, harass, harry, badger, heckle, bait, beset, infest, persecute, importune, wring, harrow, torment, torture, bullyrag, put to the rack, put to the question, break on the wheel, rack, scarify, cruciate, crucify, convulse, agonize, barb the dart, plant a dagger in the breast, plant a thorn in one's side, irritate, provoke, sting, nettle, try the patience, pique, fret, rile, tweak the nose, chafe, gall, sting to the quick, wound to the quick, cut to the quick, aggrieve, affront, enchafe, enrage, ruffle, sour the temper, give offense, maltreat, bite, snap at, assail, smite, sicken, disgust, revolt, nauseate, disenchant, repel, offend, shock, stink in the nostrils, go against the stomach, turn the stomach, make one sick, set the teeth on edge, go against the grain, grate on the ear, stick in one's throat, stick in one's gizzard, rankle, gnaw, corrode, horrify, appal, appall, freeze the blood, make the flesh creep, make the hair stand on end, make the blood curdle, make the blood run cold, make one shudder, haunt the memory, weigh on the heart, prey on the heart, weigh on the mind, prey on the mind, weigh on the spirits, prey on the spirits, bring one's gray hairs with sorrow to the grave, add a nail to one's coffin.