abuse, ado, afflict, aggrieve, annoyance, anxiety, bar, befoul, besetment, bewitch, blight, blocking, bother, burden, burthen, can of worms, cargo, charge, condemn, corrupt, cross, crucify, cumbrance, curse, damage, deadweight, defect, defile, deprave, deprivation, despoil, destroy, detriment, difficulty, disability, disaccommodate, discommode, disoblige, disserve, disservice, distress, do a mischief, do evil, do ill, do wrong, do wrong by, doom, drawback, embarrassment, encumbrance, envenom, evil, fault, flaw, freight, get into trouble, great ado, hamper, handicap, harass, harm, headache, hex, hindrance, hurt, impair, impairment, impediment, impedimenta, impose upon, imposition, incommode, inconvenience, infect, injure, injury, jinx, liability, load, loss, loss of ground, lumber, maltreat, matter, menace, mischief, mistreat, molest, obstacle, obstruction, onus, outrage, pack, peck of troubles, penalty, persecute, play havoc with, play hob with, poison, pollute, prejudice, problem, put out, put to inconvenience, put to trouble, savage, scathe, sea of troubles, shortcoming, step backward, taint, threaten, torment, torture, trouble, violate, weakness, weight, white elephant, worry, wound, wreak havoc on, wrong
evil, ill, harm, hurt, mischief, nuisance, machinations of the devil, Pandora's box, ills that flesh is heir to, blow, buffet, stroke, scratch, bruise, wound, gash, mutilation, mortal blow, wound, immedicabile vulnus, damage, loss, disadvantage
, prejudice, drawback, disaster, accident, casualty, mishap, bad job, devil to pay, calamity, bale, catastrophe, tragedy, ruin, adversity, mental suffering, demon, (Evil spirit) bane, (cause of evil), badness, (Production of Evil), painfulness, evil doer, outrage, wrong, injury, foul play, bad turn, ill turn, disservice, spoliation, grievance, crying evil, disastrous, bad, awry, out of joint, disadvantageous, amis, wrong, ill, to one's cost, moving accidents by flood and field.
inexpedience, inexpediency, undesirableness, undesirability, discommodity, impropriety, unfitness, inutility, disadvantage
, inexpedient, undesirable, unadvisable, inadvisable, objectionable, inapt, ineligible, inadmissible, inconvenient, incommodious, discommodious, disadvantageous, inappropriate, unfit, ill-contrived, ill-advised, unsatisfactory, unprofitable, unsubservient, inopportune, out of place, in the wrong place, improper, unseemly, clumsy, awkward, cumbrous, cumbersome, lumbering, unwieldy, hulky, unmanageable, impedient, unnecessary, it will never do.