abomination, affliction, aggravation, agitation, all-overs, angst, annoyance, anxiety, anxiety hysteria, anxiety neurosis, anxious bench, anxious concern, anxious seat, anxiousness, apprehension, apprehensiveness, atrocity, bad, bad news, bane, bedevilment, befoulment, blight, bore, bother, botheration, bothering, bothersomeness, bugbear, burden, calamity, cankerworm of care, care, concern, concernment, corruption, crashing bore, crushing burden, crying evil, curse, damage, death, defilement, despoliation, destruction, detriment, devilment, difficulty, disapprobation, disapproval, discontent, disease, displeasure, disquiet, disquietude, dissatisfaction, distress, disturbance, dogging, downer, drag, dread, evil, exasperation, fear, foreboding, forebodingness, grievance, harassment, harm, harrying, havoc, headache, hounding, hurt, ill, infection, infliction, injury, inquietude, irking, irritation, malaise, mischief, misgiving, molestation, nemesis, nervous strain, nervous tension, nervousness, nuisance, open wound, outrage, overanxiety, persecution, perturbation, pest, pestilence, pins and needles, plague, poison, pollution, problem, provocation, provoking, pucker, resentfulness, resentment, running sore, scourge, solicitude, stew, strain, suspense, tension, the worst, thorn, torment, toxin, trial, trouble, uneasiness, unquietness, upset, venom, vexatiousness, vexing, visitation, woe, worriment, worry, wrong, zeal
mental suffering, pain, dolor, suffering, sufferance, ache, smart, passion, displeasure, dissatisfaction, discomfort, discomposure, disquiet, malaise, inquietude, uneasiness, vexation
of spirit, taking, discontent, dejection, weariness, anhedonia, annoyance, irritation, worry, infliction, visitation, plague, bore, bother, botheration, stew, vexation
, mortification, chagrin, esclandre, mauvais quart d'heur, care, anxiety, solicitude, trouble, trial, ordeal, fiery ordeal, shock, blow, cark, dole, fret, burden, load, concern, grief, sorrow, distress, affliction, woe, bitterness, heartache, carking cares, heavy heart, aching heart, bleeding heart, broken heart, heavy affliction, gnawing grief, unhappiness, infelicity, misery, tribulation, wretchedness, desolation, despair, extremity, prostration, depth of misery, nightmare, ephialtes, incubus, pang, anguish, agony, torture, torment, purgatory, hell upon earth, iron age, reign of terror, slough of despond, peck of troubles, ills that flesh is heir to, miseries of human life, unkindest cut of all, sufferer, victim, prey, martyr, object of compassion, wretch, shorn lamb, in pain, in a state of pain, full of pain, suffering, pained, afflicted, worried, displeased, aching, griped, sore, on the rack, in limbo, between hawk and buzzard, uncomfortable, uneasy, ill at ease, in a taking, in a way, disturbed, discontented, out of humor, weary, heavy laden, stricken, crushed, a prey to, victimized, ill-used, unfortunate, to be pitied, doomed, devoted, accursed, undone, lost, stranded, fey, unhappy, infelicitous, poor, wretched, miserable, woe-begone, cheerless, careworn, concerned, sorry, sorrowing, sorrowful, cut up, chagrined, horrified, horror-stricken, in grief, plunged in grief, a prey to grief, in tears, steeped to the lips in misery, heart-stricken, heart-broken, heart-scalded, broken-hearted, in despair, the iron entered into our soul, haeret lateri lethalis arundo, one's heart bleeding, down, thou climbing sorrow, mirth cannot move a soul in agony, nessun maggior dolere che ricordarsi del tempo fel, sorrow's crown of sorrow is remembering happier th, the Niobe of Nations.
painfulness, trouble, care, trial, affliction, infliction, blow, stroke, burden, load, curse, bitter pill, bitter draught, waters of bitterness, annoyance, grievance, nuisance, vexation
, mortification, sickener, bore, bother, pother, hot water, sea of troubles, hornet's nest, plague, pest, cancer, ulcer, sting, thorn, canker, scorpion, dagger, scourge, carking care, canker worm of care, mishap, misfortune, desagrement, esclandre, rub, source of irritation, source of annoyance, wound, open sore, sore subject, skeleton in the closet, thorn in the flesh, thorn in one's side, where the shoe pinches, gall and wormwood, sorry sight, heavy news, provocation, affront, head and front of one's offending, infestation, molestation, malignity, causing pain, hurting, hurtful, painful, dolorific, dolorous, unpleasant, unpleasing, displeasing, disagreeable, unpalatable, bitter, distasteful, uninviting, unwelcome, undesirable, undesired, obnoxious, unacceptable, unpopular, thankless, unsatisfactory, untoward, unlucky, uncomfortable, distressing, afflicting, afflictive, joyless, cheerless, comfortless, dismal, disheartening, depressing, depressive, dreary, melancholy, grievous, piteous, woeful, rueful, mournful, deplorable, pitiable, lamentable, sad, affecting, touching, pathetic, irritating, provoking, stinging, annoying, aggravating, mortifying, galling, unaccommodating, invidious, vexatious, troublesome, tiresome, irksome, wearisome, plaguing, plaguy, awkward, importunate, teasing, pestering, bothering, harassing, worrying, tormenting, carking, intolerable, insufferable, insupportable, unbearable, unendurable, past bearing, not to be borne, not to be endured, more than flesh and blood can bear, enough to drive one mad, enough to provoke a saint, enough to make a parson swear, enough to gag a maggot, shocking, terrific, grim, appalling, crushing, dreadful, fearful, frightful, thrilling, tremendous, dire, heart-breaking, heart-rending, heart-wounding, heart-corroding, heart-sickening, harrowing, rending, odious, hateful, execrable, repulsive, repellent, abhorrent, horrid, horrible, horrific, horrifying, offensive, nauseous, nauseating, disgusting, sickening, revolting, nasty, loathsome, loathful, fulsome, vile, hideous, sharp, acute, sore, severe, grave, hard, harsh, cruel, biting, caustic, cutting, corroding, consuming, racking, excruciating, searching, grinding, grating, agonizing, envenomed, catheretic, pyrotic, ruinous, disastrous, calamitous, tragical, desolating, withering, burdensome, onerous, oppressive, cumbrous, cumbersome, painfully, with pain, deuced, Int, hinc illae lachrymae!, surgit amari aliquid, the place being too hot to hold one, the iron entering into the soul, he jests at scars that never felt a wound, I must be cruel only to be kind, what deep wounds ever closed without a scar?.