adherent, adhesive, affliction, annoyance, bane, barb, barnacle, bitter cup, bitter draft, bitter draught, bitter pill, bother, bramble, brier, bristle, bugbear, bulldog, burden, burden of care, burr, cactus, calamity, cankerworm of care, care, catchweed, cement, cleavers, cross, crown of thorns, crushing burden, curse, death, decal, decalcomania, destruction, disease, distress, encumbrance, evil, gall, gall and wormwood, glue, goose grass, grievance, gunk, harm, infliction, irritant, irritation, leech, limpet, load, molasses, mucilage, needle, nemesis, nettle, nuisance, open wound, oppression, pack of troubles, paste, peck of troubles, pest, pestilence, pine needle, plague, plaster, point, prickle, quill, remora, running sore, scourge, sea of troubles, sorrow, spicule, spiculum, spike, spikelet, spine, sticker, syrup, thistle, torment, torture, trouble, vexation, visitation, waters of bitterness, weight, woe, yucca
bane, curse, evil, hurtfulness, painfulness, scourge, damnosa hereditas, white elephant, sting, fang, thorn
, tang, bramble, brier, nettle, poison, toxin, teratogen, leaven, virus venom, arsenic, antimony, tartar emetic, strychnine, nicotine, miasma, miasm, mephitis, malaria, azote, sewer gas, pest, Albany hemp, arsenious oxide, arsenious acid, bichloride of mercury, carbonic acid, carbonic gas, choke damp, corrosive sublimate, fire damp, hydrocyanic acid, cyanide, Prussic acid, hydrogen cyanide, marsh gas, nux vomica, ratsbane, hemlock, hellebore, nightshade, belladonna, henbane, aconite, banewort, bhang, ganja, hashish, Upas tree, Toxline (online), rust, worm, helminth, moth, moth and rust, fungus, mildew, dry rot, canker, cankerworm, cancer, torpedo, viper, demon, toxicology, baneful, poisonous, phr, bibere venenum in auro, Contingent Subservience.
painfulness, trouble, care, trial, affliction, infliction, blow, stroke, burden, load, curse, bitter pill, bitter draught, waters of bitterness, annoyance, grievance, nuisance, vexation, mortification, sickener, bore, bother, pother, hot water, sea of troubles, hornet's nest, plague, pest, cancer, ulcer, sting, thorn
, canker, scorpion, dagger, scourge, carking care, canker worm of care, mishap, misfortune, desagrement, esclandre, rub, source of irritation, source of annoyance, wound, open sore, sore subject, skeleton in the closet, thorn
in the flesh, thorn
in one's side, where the shoe pinches, gall and wormwood, sorry sight, heavy news, provocation, affront, head and front of one's offending, infestation, molestation, malignity, causing pain, hurting, hurtful, painful, dolorific, dolorous, unpleasant, unpleasing, displeasing, disagreeable, unpalatable, bitter, distasteful, uninviting, unwelcome, undesirable, undesired, obnoxious, unacceptable, unpopular, thankless, unsatisfactory, untoward, unlucky, uncomfortable, distressing, afflicting, afflictive, joyless, cheerless, comfortless, dismal, disheartening, depressing, depressive, dreary, melancholy, grievous, piteous, woeful, rueful, mournful, deplorable, pitiable, lamentable, sad, affecting, touching, pathetic, irritating, provoking, stinging, annoying, aggravating, mortifying, galling, unaccommodating, invidious, vexatious, troublesome, tiresome, irksome, wearisome, plaguing, plaguy, awkward, importunate, teasing, pestering, bothering, harassing, worrying, tormenting, carking, intolerable, insufferable, insupportable, unbearable, unendurable, past bearing, not to be borne, not to be endured, more than flesh and blood can bear, enough to drive one mad, enough to provoke a saint, enough to make a parson swear, enough to gag a maggot, shocking, terrific, grim, appalling, crushing, dreadful, fearful, frightful, thrilling, tremendous, dire, heart-breaking, heart-rending, heart-wounding, heart-corroding, heart-sickening, harrowing, rending, odious, hateful, execrable, repulsive, repellent, abhorrent, horrid, horrible, horrific, horrifying, offensive, nauseous, nauseating, disgusting, sickening, revolting, nasty, loathsome, loathful, fulsome, vile, hideous, sharp, acute, sore, severe, grave, hard, harsh, cruel, biting, caustic, cutting, corroding, consuming, racking, excruciating, searching, grinding, grating, agonizing, envenomed, catheretic, pyrotic, ruinous, disastrous, calamitous, tragical, desolating, withering, burdensome, onerous, oppressive, cumbrous, cumbersome, painfully, with pain, deuced, Int, hinc illae lachrymae!, surgit amari aliquid, the place being too hot to hold one, the iron entering into the soul, he jests at scars that never felt a wound, I must be cruel only to be kind, what deep wounds ever closed without a scar?.