Adjective has 2 senses

• nettlesome(s = adj.all) annoying, bothersome, galling, irritating, pesky, pestering, pestiferous, plaguey, plaguy, teasing, vexatious, vexing - causing irritation or annoyance; "a pesky mosquito"; "a plaguey newfangled safety catch"; "a teasing and persistent thought annoyed him"; "a vexatious child"; "aircraft noise is particularly bothersome near the airport"; "an irritating delay"; "found it galling to have to ask permission"; "it is vexing to have to admit you are wrong"; "nettlesome paperwork"; "swarms of pestering gnats"; "tapping an annoying rhythm on his glass with his fork"


• nettlesome(s = adj.all) cranky, fractious, irritable, peckish, peevish, pettish, petulant, scratchy, techy, testy, tetchy - easily irritated or annoyed; "an incorrigibly fractious young man"; "not the least nettlesome of his countrymen"